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Monday, June 10, 2019

Pharmacoinformatics: A Tool for Drug Discovery






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Pharmacoinformatics is new emerging information technologies like neuroinformatics, immunoinformatics, bioinformatics, Metabolomics, chemo-informatics, toxico-informatics, cancer informatics, genome informatics, proteome informatics, biomedical informatics are basic tools provided for the purpose of drug discovery. There is an increasing recognition that information technology can be effectively used for drug discovery. The work in pharmacoinformatics can be broadly divided into two categories -scientific aspects and service aspects. The scientific component deals with the drug discovery and development activities whereas the service-oriented aspects are more patient-centric. The compelling drivers for the pharmaceutical industry are minimizing the time between a drug's discovery and its delivery to the marketplace and maintaining high productivity in the manufacturing processes. During a product's lifecycle, many complex decisions must be made to achieve these goals. To better support the development and manufacturing processes at each stage, we have proposed a new epitome to facilitate the management and transfer of data information and knowledge. In the future, these information technology efforts are expected to grow both in terms of their reliability and scope. Thus, this emerging technology (pharmacoinformatics) is becoming an essential component of the pharmaceutical sciences.

How to Write a Better Thesis




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This book offers a step-by-step guide on the mechanics of thesis writing. It helps readers to understand how to conceptualize and approach the problems of producing a thesis and illustrates the complete process with concrete examples

medicinal chemistry by Ashutosh Khar



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Medicinal chemistry by Ashutosh Khar is one of the best book for Pharma students.
This extremely successful textbook emphasizes the fundamentals of medicinal chemistry with specific reference to drug design, drug synthesis, and drug action from a pharmaceutical organic chemical perspective. Thus, it really enables the reader to extend knowledge beyond what is known with regard to several known classes of drug molecules. Particular care has been taken to preserve the organization, presentation, and rhythm of the fourth edition.

pharmacoepidemiological study of Epilepsy in south India

Sunday, May 26, 2019

Indian Pharmacopoeia


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The Indian Pharmacopoeia Commission (IPC) is an autonomous institution under the Ministry of Health and Family Welfare which is responsible to set standards of drugs in the country. Details of Indian Pharmacopoeia (IP) such as Monographs inclusion-exclusion criteria, development of IP Monograph, a guideline for the formatting of Monographs, IP review process, a distribution network for IP, etc. are available. Users can also find information on IP Reference Spectra, IP Reference Substances (IPRS), IP Compliance, Common Queries on IP, National Formulary of India (NFI), Indian Pharmacopoeia Laboratory (IPL), new drugs testing at IPL, etc. Frequently asked questions (FAQs) about the Commission is given. One can also access information of memorable events, tender documents, Right to Information Act (RTI), contact details, news and articles about IPC

Martins Physical Pharmacy and Pharmaceutical Sciences



Considered the most comprehensive text available on the application of the physical, chemical and biological principles in the pharmaceutical sciences, this book helps students, teachers, researchers, and industrial pharmaceutical scientists use elements of biology, science, and chemistry in their work and study.
Since the first edition was published in 1960, the text has been and continues to be a required text for the core courses of Pharmaceutics, Drug Delivery, and Physical Pharmacy. This edition features expanded content on drug delivery, solid oral dosage forms, pharmaceutical polymers, and pharmaceutical biotechnology, and updated sections to cover advances in nanotechnology.

Wednesday, May 22, 2019

Atomic absorption spectroscopy short notes


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Since we all know that understanding the concept of spectroscopy is not much easy task.
So we have collected and arranged notes in a very easy manner.
I hope you will get it all.
thank you
If you like it then share it with your friends and needed a person

CLINICAL PHARMACY





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Clinical pharmacy is a health science discipline in which pharmacists provide patient care that optimizes medication therapy and promotes health, and disease prevention. The practice of clinical pharmacy embraces the philosophy of pharmaceutical care, blending a caring orientation with specialized therapeutic knowledge, experience, and judgment to ensure optimal patient outcomes. As a discipline, clinical pharmacy also has an obligation to contribute to the generation of new knowledge that advances health and quality of life

Saturday, May 18, 2019

Ross and Wilson Anatomy and Physiology in Health and Illness, 12 edittion




Ross and Wilson have been the number one choice for over a million students since it first published, over 50 years ago. One of the world's most popular textbooks of anatomy and physiology, it introduces the structure and functions of the human body and the effects of disease or illness on normal body function. More than any other text Ross and Wilson uses easy-to-understand, straightforward language, enhanced by color illustrations and a huge range of interactive online activities, to make learning more visual and engaging.
Ross and Wilson is essential reading for anyone embarking on a career as a healthcare professional, especially in the nursing and allied health professions, complementary/alternative medicine or as paramedics and ambulance technicians.
"There are new sections on the implications of normal aging on the structure and function of the body systems. The glossary has been expanded, as have the online access, learning outcomes and normal values tables. This book is excellent value for money." Reviewed by: Nursing Standard Date: Aug 2014
  • The carefully refined, clear and unambiguous text which omits the unnecessary detail that can confuse the student new to the subject
  • Highly illustrated with clear color diagrams and photographs
  • Regular sequences of headings, lists and bullet points help with learning and revision
  • Learning outcomes related to the sections within each chapter
  • Common prefixes, suffixes, and roots commonly used in anatomy and physiology
  • An appendix containing useful biological values for easy reference
  • Access to additional electronic resources, including high-quality animations, coloring exercises, case studies, self-testing questions, an audio pronunciation guide, and weblinks
  • An accompanying Colouring and workbook that facilitates structured learning and revision of the material in this book.
    • Fully revised and updated text, with a focus on the most commonly occurring disorders
      • New sections on the implications of normal aging on the structure and function of the body systems to reinforce the core material and reflect today's aging population
        • A new, easy-to-use coloring feature has been added to the extensive and varied selection of highly popular web-based online revision activities
          • Additional colored electron micrographs and photographs, as well as updated illustrations
            • Extended glossary for fast, convenient and concise reference to important terminology




            Tartora Essentials of Anatomy and Physiology



            Essentials of Anatomy and Physiology enables allied health professionals to efficiently and effectively master the essentials of anatomy and physiology as well as understand the balance between homeostasis and disruptions to homeostasis. Features such as Looking Back to Move Ahead help refresh basic concepts and make connections from system to system and concept to concept. Rich in clinical resources that highlight disruptions to homeostasis, the book also includes a special box in each chapter that focuses on Wellness. These unique discussions help allied health professionals make the connections between knowledge of form and function with optimal healthy choices


            Introduction to Spectroscopy– by Donald L. Pavia (Author)



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            Introduce your students to the latest advances in spectroscopy with the text that has set the standard in the field for more than three decades: INTRODUCTION TO SPECTROSCOPY, 5e, by Donald L. Pavia, Gary M. Lampman, George A. Kriz, and James R. Vyvyan. Whether you use the book as a primary text in an upper-level spectroscopy course or as a companion book with an organic chemistry text, your students will receive an unmatched, systematic introduction to spectra and basic theoretical concepts in spectroscopic methods. This acclaimed resource features up-to-date spectra a modern presentation of one-dimensional nuclear magnetic resonance (NMR) spectroscopy an introduction to biological molecules in mass spectrometry and coverage of modern techniques alongside DEPT, COSY, and HECTOR.

            Wednesday, May 15, 2019

            Top 100 Drugs Of Choice For Different Diseases














            Top 100 Drugs Of Choice For Different  Diseases


            Drugs of choice for different diseases are categorized on the basis of diseases. Following are the most important classes of drugs used as a first choice in the treatment of different diseases.


            Drugs Of Choice List in pregnancy

            (1)Chloroquine
            • Drug of choice for malaria in pregnancy
            (2) Alpha-Methyldopa
            • Drug of choice for hypertension in pregnancy
            (3) Femara
            • For breast cancer.
            (4) Labetalol
            • For the hypertensive crisis in pregnant women.
            (5) Acetaminophen
            • Analgesic DOC
            (6) Phenobarbitone
            • For epilepsy in pregnant women.
            (7) Doxylamine & Pyridoxine
            • For nausea in pregnancy

            Drugs Of Choice List in infections

            (8) Penicillin G
            Drug of choice in
            • Septicemia,
            • Meningitis,
            • Pericarditis,
            • Endocarditis and
            • Severe pneumonia.
            (9) Ampicillin
            Drug of choice in
            • Listeria,
            • Enterococcus faecalis.
            (10) Vancomycin
            Drug of choice for
            • MRSA,
            • Coagulase-negative Staphylococcus,
            • Enterococcus faecium.
            (11) Erythromycin
            Drug of choice for
            • Corynebacterium
            (12) Doxycycline
            • Bacillus anthracis,
            • Borrelia burgdorferi, B.Recurrentis.
            • Chalmydia & Rickettsiae.
            (13) Cotrimoxazole
            Drug of choice in
            • Nocardia
            (14) Azithromycin
            Drug of choice in
            • Hemophilus ducreyi &
            • Mycoplasma .
            (15) Ceftriaxone
            Drug of choice for
            • Proteus,
            • E.coli,
            • Salmonella
            Drug of choice for
            • Urinary Tract Infection
            (17) Metronidazole
            Drug of choice for
            • Bacteriocides
            (18) Ceftazidime
            DOC for
            • Burkholderia pseudomallei

            Drugs Of Choice List for various types of seizures

            (19) Valproate
            Drug of choice for
            • Tonic seizures
            • Absence seizures
            • Grand mal (GTCS)
            • Clonic seizures
            • Atonic seizures
            • Myoclonic seizures
            (20) Carbamazepine
            • Partial seizures
            (21) Vigabatrin
            • Infantile spasm with tuberous sclerosis
            (22) ACTH
            • Infantile spasm
            (23) Lorazepam (IV)
            • Status epilepticus
            (24) Diazepam
            • Febrile seizures
            (25) Magnesium Sulphate
            • Seizure in eclampsia

            Drugs Of Choice List in poisoning

            (26) Physostigmine
            • Atropine,
            • Belladonna  &
            • Dhatura poisoning
            (27) Atropine
            • Carbamate,
            • Early mushroom poisoning,
            • Organophosphate poisoning.
            (28) Flumazenil
            • Benzodiazepine poisoning
            (29) Acetylcysteine
            • Acetaminophen poisoning
            (30) Naloxone
            • Opioid poisoning
            (31) Deferiprone
            • Chronic iron poisoning
            (32) Desferrioxamine
            • Acute iron poisoning
            (33) Glucagon
            • Beta-blockers poisoning
            (34) Amyl nitrate
            • Cyanide poisoning

            Drugs Of Choice List in bronchial asthma

            (35) Salbutamol
            Salbutamol is the drug of choice for
            • An acute attack of bronchial asthma in normal patient and pregnant women.
            • Exercise & Aspirin-induced acute attack of bronchial asthma.
            (36) Ipratropium
            • An acute attack of bronchial asthma during labor.
            • An acute attack of bronchial asthma on beta-blocker therapy.
            (37) Corticosteroids
            • Prophylaxis of bronchial asthma,
            • Exercise-induced, and
            • Aspirin-induced asthma.

            Drugs Of Choice List In Antimicrobials Prophylaxis

            (38) Ampicillin
            • Group B streptococcus infection
            (39) Amoxicillin
            • Endocarditis and Otitis media
            (40) Azithromycin
            • Mycobacterium avium complex (MAC) Pertussis
            (41) Benzathine penicillin
            • Rheumatic fever
            (42) Procaine Penicillin
            • Gonorrhea and syphilis
            (43) Tetracycline
            • Rickettsial infection and plague.
            (44) Cefazoline
            • Surgical Prophylaxis
            (45) Doxycycline
            • Anthrax
            (46) Trimethoprim and sulphamethoxazole
            • Toxoplasmosis,
            • Pneumocystis service UTI
            (47) Rifampicin
            • Hemophilus influenza type B.
            (48) Oseltamivir
            • Influenza Type A & B.

            Anesthetic Drugs Of Choice List

            (49) Propofol
            • Daycare
            (50) Sevoflurane
            • Congenital heart disease,
            • ASD,VSD,PDA
            (51) Etomidate
            • Ischemic heart disease
            (52) Ketamine
            • Asthma and COPD
            • Shock
            • CHF, and
            • congenital heart disease (Right to left shunt)
            (53) Thiopentone
            • Epilepsy
            • Thyrotoxicosis
            (54) Methohexitone
            • Electroconvulsive therapy
            (55) Isoflurane
            • Cardiac surgery
            • Neurosurgery
            • For producing deliberate hypotension

            Drugs Of Choice List in Endocrinological Disorders

            (56) Insulin
            • Type 1 DM
            • Diabetes Mellitus in pregnancy.
            • Diabetic Ketoacidosis.
            • Uncontrolled DM.
            (57) Metformin
            • Type 2 DM
            • Diabetes mellitus in obesity
            (58) Sildenafil
            • Erectile Dysfunction
            (59) Hydrocortisone
            • Acute and chronic adrenal insufficiency.
            (60) Nateglinide
            • Postprandial hyperglycemia.
            (61) Methotrexate
            • Ectopic pregnancy
            (62) Oxytocin
            • Postpartum hemorrhage
            • Induction of labor
            (63) Cabergoline
            • Acromegaly
            • Hyperprolactinemia.
            (64) Finasteride
            • Anogenital alopecia.
            (65) Alendronate
            • Osteoporosis

            Drugs of choice in fungal infections

            (66) Amphotericin B
            Amphotericin B is the drug of choice in
            • Meningeal histoplasmosis
            • Endocarditis by candida
            • Sever or CNS blastomycosis
            • Induction  cryptococcal meningitis(For 2 weeks)
            • Exserohium
            (67) Fluconazole
            • Candida albicans
            • Maintainance in cryptococcal meningitis
            (68) itraconazole
            • Nonmeningeal histoplasmosis
            • Sporotrichosis
            • Para Coccidioidomycosis
            • Mild or non-CNS blastomycosis
            • Chromoblastomycosis
            • Penicillium mameffei
            (69) Prednisolone+itraconazole/Voriconazole
            • Allergic bronchopulmonary aspergillosis.
            (70) Caspofungin
            • Candida glabrate, and
            • Candida krusei.

            Drugs of choice in gastrointestinal disorders

            (71) PPIs (Proton Pump Inhibitors)
            • Gastric ulcer,
            • Duodenal ulcer,
            • stress ulcer,
            • NSAIDs-induced ulcer.
            • GERD,& Zollinger Ellison syndrome.
            (72) Metoclopramide
            • A migraine associated or drug or disease associated vomiting
            (73) Domperidone
            • Levodopa-induced vomiting
            (74) Ondansetron
            • Postoperative or radiation-induced vomiting
            (75) 5HT3 antagonist
            • Cisplatin-induced early vomiting
            (76) Lactulose
            • Hepatic encephalopathy
            (77) Methylnaltrexone
            • Opioid-induced constipation
            (78) Octreotide
            • Diarrhea in carcinoid syndrome

            Drugs of choice in Hematological Disorders

            (79) Warfarin
            • DVT prophylaxis
            • Chronic atrial fibrillation in mitral stenosis,
            • Advanced kidney disease, and
            • mechanical prosthetic heart valves
            (80) Heparin+Warfarin
            • Initiation of therapy in DVT.
            (81) Vitamin K
            • Warfarin overdose
            (82) Protamine
            • Heparin overdose

            Drugs of Choice in Hypertension

            (83) Thiazide diuretics
            • Hypertension
            (84) Prazosin
            • Hypertension With BPH
            (85) Beta Blockers
            • Hypertension with ischemic heart disease.(Angina)
            (86) ACE inhibitors
            • Hypertension with chronic kidney diseases.
            (87) Alpha methylDopa
            • Hypertension in pregnancy
            (88) Phentolamine
            • Hypertensive emergencies with cheese reaction
            (89) Nitroprusside+Esmolol
            • Hypertensive emergencies in aortic dissection.
            (90) Labetalol
            • Hypertensive emergencies in pregnancy.

            Drugs of choice in shock

            (91) Adrenaline
            • Anaphylactic shock
            (92) Dopamine or noradrenaline
            • Cardiogenic shock
            (93) Phenylephrine
            • Distributive shock
            (94) Prazosin
            • Secondary shock
            (95) Dopamine
            • Shock with oliguria
            (96) Corticosteroids
            • Shock due to adrenal insufficiency

            Drugs of choice For viral diseases

            (97) Ribavirin
            • Viral hemorrhagic fever
            • Measles
            • Respiratory syncytial virus(in high-risk patient
            (98) Zanamivir
            • Oseltamivir-resistant influenza
            • Oseltamivir
            • Seasonal influenza and avian influenza (bird flu)
            (99) Acyclovir
            • Herpes simplex and varicella.
            • Valacyclovir
            • Acute herpes zoster.
            (100) Gancyclovir
            • Cytomegalovirus retinitis.

            Monday, May 13, 2019

            important drug drug interaction


            GPAT previous year quetion paper


            Medicinal Chemistry Handwritten Notes 1st

            During exam time most of the students don't have short notes for a quick and complete revision. To solve this problem I have discussed with my classmate DRx. Anjana Kushwaha and my junior DRx Shivam Mishra and prepared some concise and comprehensive notes on MEDICINAL CHEMISTRY. 
            Note- not all topics but some topics are discussed in this pdf. Read all the topics carefully, there will be a chance of silly mistakes but the matter in the notes is marks scoring. 
            Dear student if you like these notes then please share with your classmates and needed person.


             DOWNLOAD BOOK FROM HERE

            Sunday, May 12, 2019

            medicinal chemistry Handwritten notes 2nd

            During exam time most of the students don't have short notes for quick and complete revision. To solve this problem I have discussed with my classmate DRx. Anjana Kushwaha and prepared some concise and comprehensive  notes on MEDICINAL CHEMISTRY. 
            Note- not all topics but some topics are discussed in this Pdf . Read all the topics care fully , there will be a chance of silly mistakes but matter in the notes is marks scoring. 
            Dear student if you like these notes then please share with your classmates and needed person.



            Sunday, April 28, 2019

            Burger's Medicinal Chemistry, Drug Discovery, and Development, 6rd Volume Set 7th Edition



            Burger's Medicinal Chemistry, Drug Discovery, and Development provide a comprehensive source of medicinal chemistry and drug discovery and development. This authoritative resource incorporates the entire drug development cycle (preclinical testing, clinical trials, etc.), alongside medicinal chemistry and drug discovery.
            Now in its seventh edition, Burger's Medicinal Chemistry, Drug Discovery, and Development provide an established, recognized, authoritative and comprehensive source on medicinal chemistry and drug discovery and development. This flagship reference for medicinal chemists and pharmaceutical professions has been thoroughly updated and expanded across 8 volumes to incorporate the entire process of drug development (preclinical testing, clinical trials, etc.) alongside the traditional strengths in medicinal chemistry and drug discovery

            Textbook of Medicinal Chemistry Volume 2: Alagarsamy V

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            Textbook of Medicinal Chemistry volume 1 is a widely appreciated text on the subject. Primarily meant for BPharm students, this book is also useful for MPharm and MSc students studying organic chemistry and pharmaceutical chemistry. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing valuable information on relevant topics. The text adequately covers the syllabi of all major Indian universities.
            The third edition features a new layout and design in an attractive two-color presentation.
            Salient Features
            Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure-activity relationship (SAR) of the drugs for the various body systems
            Contains a complete section on drug design, describing the new drug development
            Contains brief introduction about physiological and pathophysiological conditions of diseases and their treatment
            Provides well-illustrated synthetic schemes and alternative synthetic routes for the majority of drugs that help in quick and enhanced understanding of the subject
            Additional physicochemical parameters have been explained
            Chapters on Partition Coefficient and Solubility given under the section Physicochemical Factors in Relation to Biological Activity of Drugs
            The chapter on High Throughput Screening added under the section Drug Design
            Several newer drugs incorporated in different chapters

            Goodman and Gilman's The Pharmacological Basis of Therapeutics

              The best book on Pharmacology without a doubt, none comes close to the depth of knowledge this book has.  Though font size is small, paper...